Senile disease in children
Senile disease in children Hutchinson-Gilford Progeria Syndrome (HGPS)
It is known that Animals and humans have a circulating cycle of life from birth to death, which is also found within the bodies of animals and humans. Cells are divided into new cells to replace old cells that have died and become dead. In addition, cells that grow are likely to have the aging process. This is because as cells get older they tend to have more waste accumulation. And cell aging may also be related to genes.
Therefore, cellular aging is what determines the life expectancy of an organism. In addition, life expectancy is regulated by genes and the environment. Abnormalities in which cells age faster than normal. Causing aging in children Hutchinson-Gilford Progeria Syndrome (HGPS), also known as Progeria Syndrome. Or Werner syndrome (Progeria or found in children, both female and male The disease is found in only 1 in 8 million people, with 90% of children suffering from the disease caused by mutation of the Lmna gene, which leads to abnormal laminA synthesis. Cells will age faster than normal. Characteristics of children with this disease are similar to normal children in the first 10 to 24 months, after which growth will begin very slowly. Stunted body, low weight, aging quickly and easily tired, symptoms such as Werner Syndrome)
- thin skull Out of proportion The chest area looks like a pear-shaped fruit and has anchoring symptoms because there is a chart in the area of the joint. Hip dislocation The legs are stretched out like a rider.
- The front bone is not growing. The face and jaws are smaller than usual, bulging eyes, small and prominent nose. Small treble Baby and permanent teeth grow more slowly than normal. Up, messy and easy to fall off Hair and hair will fall over bald
- the skin is wrinkled like an old man The skin around the head is thin and clear until the blood vessels are visible.
- Abnormal nails can be seen from infancy. Nails are easily broken and yellow. Or in some cases there will be no nails at all
Children with this disease deteriorate in health every year. When the patient’s average age is about 10 years, there will be various illnesses. As in the elderly, for example, there is an increase in heart disease symptoms High blood pressure and arthritis in some patients requiring coronary artery surgery (Bypass), most patients die from heart failure. And cerebrovascular disease
There is currently no cure for this disease. Only symptomatic treatment or Lmna testing can be performed at the molecular level for pregnant women. People with progeny all over the world, although they differ in ethnicity. But the symptoms of the disease are expressed the same. And usually die between the ages of 8 – 21 or the average age of about 13