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Acetylcysteine, also known as N-acetylcysteine, is a medication that is used to treat paracetamol overdose, and to loosen thick mucus in individuals with chronic bronchopulmonary disorders like pneumonia and bronchitis. It can be taken intravenously, by mouth, or inhaled as a mist. Wikipedia

Acetylcysteine is an expectorant or expectorant drug. Used to treat illnesses caused by overdose of paracetamol. to prevent liver damage and treating the condition where the mucus becomes thick and sticky, causing breathing problems From conditions or diseases related to respiratory organs such as bronchitis, emphysema, pneumonia, pneumonia, etc., the drug will help dissolve thick mucus to be diluted. To allow the respiratory system to drive those mucus out. and help the patient to breathe more easily in the end.

Drug Group: expectorant
Drug Type: prescription medication
Properties: Dissolve phlegm, break down thick, sticky mucus to be lighter.
Patient Group: young and old
Dosage Form: Intravenous drug, oral medication
Formula: C5H9NO3S
Other names: N-acetylcysteine; N-acetyl-L-cysteine; NALC; NAC
Metabolism: Liver
Elimination half-life: 5.6 hours

About Cylcysteine

  • If you have ever had an allergic reaction to this drug If you are allergic to it or any of the ingredients in this drug, you should never take Acetylcysteine ​​and tell your doctor.
  • If the patient has ever had a drug allergy, food allergy, or allergy to any kind of substance. You should inform your doctor before using the drug. Because the components of the drug may contain allergens that can cause allergic reactions in some patients.
  • Before using the drug, the patient must report a significant medical history. especially with asthma or have ulcers in the stomach and intestines
  • in pregnant patients Physicians need to consider the benefits and side effects of the medication by talking to the patient before using it.
  • If the patient is in a state of lactation Be sure to let your doctor know and consult your doctor before using the drug. Since there is no clear test result whether the drug will pass through breast milk and affect the baby.
  • if treated with medication Acetylcysteine and the symptoms have not improved, have worsened, have breathing problems or have signs of an allergic reaction to the drug You should notify your doctor immediately.

Dosage Acetylcysteine

Example of drug dosage Acetylcysteine to treat symptoms from an overdose of paracetamol

adults and children

  • intravenous injection —- Administer 300 mg/kg of body weight in 3 divided doses within 21 hours, with a dose of 150 mg/kg body weight. or let the drug be slowly absorbed into a vein over 60-120 minutes, followed by 50 mg/kg of body weight. or administered gradually into a vein over 4 hours, followed by 100 mg/kg of body weight or intravenously gradually over 16 hours, initiate a single dose of 140 mg/kg body weight, then, after 4 hours, initiate an oral dose of 70 mg/kg every single dose. 4 hours, 17 times, or until the level of toxicity in the body from an overdose of paracetamol is not detected.

Example of drug dosage Acetylcysteine to reduce the condition of thick sputum

oral medication

Patients must take it continuously for 5-10 days or as prescribed by the doctor.


  • Adults and children over 14 years old take 1 capsule 2-3 times a day.
  • Children over 6 years old : Take 1 capsule twice a day after meals.

powder medicine

  • Adult : Take 1 sachet (200 mg) 2-3 times/day.
  • Children over 6 years old take 1 sachet (100 mg) per time, 2-4 times/day.

water pill

  • Adults take 10 ml 2-3 times a day.
  • Children take 5 ml 2-4 times/day.
  • Children over 4 years old, 300 mg/day orally
  • Children 2-4 years old, 200 mg/day orally
  • Children under 2 years old : 100 mg/day orally

Acetylcysteine ​​use

Acetylcysteine ​​use to prevent illness and potential liver damage from an overdose of paracetamol. or to prevent potential kidney damage from the use of contrast mediums to assist with X-ray imaging or CT scan procedures. Doctors may prescribe oral or injectable medications in the appropriate dosages. Therefore, the patient must use the medication. Only according to the dosage and method prescribed by the doctor. To prevent dangerous side effects from taking the drug. When in doubt about medication Always ask your doctor for a thorough understanding first.

If the patient forgets to take the drug in a period of time Take the medicine as soon as you remember. But if it’s close to the time of taking the next round of pills Skip this pill and take the next pill instead. using the usual dosage do not increase the dosage Do not take more than the dose prescribed at a time.

After taking the medication, if possible, the patient should try to cough to expel the mucus that has weakened after the medication has been used. If the patient is unable to expel phlegm on their own A medical procedure may be needed to suck the mucus out. This prevents thick mucus from forming in the lungs and causing respiratory problems.

medicine storage section The medication must be used as soon as the package is opened. Do not leave the bottle cap open. Store the sealed package in the refrigerator. But the medicine must not be stored in the freezer. The medicine must be kept in a position out of the reach of children. and dispose of the medicine if the bottle has been left open for more than 4 days, if the medicine has expired, or when the medicine is no longer needed.

In addition, while using the drug Acetylcysteine Your doctor may need to check for any symptoms and side effects through lab tests, such as blood tests. Patients should always cooperate with their doctor. or visit a doctor by appointment

side effects from medication Acetylcysteine

Many patients do not face dangerous side effects from their use. Acetylcysteine ​​in any way, or may experience minor side effects from the drug. Some of the possible side effects from using this medication include:

  • cold, runny nose
  • cold skin
  • sleepy
  • have a fever
  • Inflammation and irritation of the mouth or tongue
  • Nausea, vomiting

Although the above side effects may be mild illnesses. but if such symptoms do not abate is still chronically ill or have more severe symptoms Patients should see a doctor for further examination and treatment.

The side effects are very rare. but violent And patients should seek medical help immediately. When experiencing the following symptoms

  • A rash, hives, on the skin
  • swollen face, swollen lips, swollen tongue
  • shortness of breath, tightness in the chest
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